The 'This Means War' actress - who has daughter Ava, 12, and son Deacon, eight, with ex-husband Ryan Phillippe - is very happy with current husband Jim Toth and wants to have a family with him.
Asked about the possibility of having more children, she said: "I would love that. I'm really happy.
"I feel really good and I'm at a really good place in my life."
The 36-year-old actress - who married Hollywood agent Jim last March - advised working parents to "enjoy" every minute because children grow up so quickly.
She told Us Weekly magazine: "Every working mother has to balance work and the children and just enjoy it, because it all goes very fast."
Reese recently admitted she is very "proud" of how she and Ryan have raised their kids and says she will always put her family first.
She said: "My ex-husband and I co-parent really well. We really balance each other's schedules and just communicate a lot.
"Nothing's more important for me than family. I definitely love having a career, but I just love being a mom - it's how I was raised."