The Swedish singer's family confirmed the news this morning, with heartfelt tributes pouring in online.
Marie Fredriksson, vocalist with Roxette had enjoyed a long, successful career with bandmate, Per Gessle, despite a long battle with cancer.
The vocalist behind It Must Have Been Love and Listen to Your Heart was diagnosed with a brain tumour 17 years ago. She underwent surgery and a long chemotherapy treatment plan which left her blind in one eye, with limited hearing and unable to speak for some time.
But, Marie's love of music kept her motivated, and she eventually made her way back to music and touring with Roxette.
Marie’s management team were first to announce the news, stating: “Marie leaves us a grand musical legacy. Her amazing voice - both strong and sensitive - and her magical live performances will be remembered by all of us who were lucky enough to witness them.
"But we also remember a wonderful person with a huge appetite for life, and a woman with a very big heart who cared for everybody she met."
Bandmater, Per, issued a statement online that paid trbute to the star:
"Time goes by so quickly. It’s not that long ago we spent days and nights in my tiny apartment in Halmstad, listening to music we loved, sharing impossible dreams. And what a dream we eventually got to share!
"Thank you, Marie, thanks for everything. You were an outstanding musician, a master of the voice, an amazing performer. Thanks for painting my black-and-white songs in the most beautiful colors. You were the most wonderful friend for over 40 years. I’m proud, honored, and happy to have been able to share so much of your time, talent, warmth, generosity, and sense of humor. All my love goes out to you and your family. Things will never be the same.”