The Hollywood power couple discussed the brave decision for Angelina to undergo preventative surgery in a new joint interview.
Brad and Angelina opened up about the decision to undergo a preventative double mastectomy in 2013 and removal of ovaries earlier this year, in a recent interview with the US version of The Today Show.
"There was no vanity to my wife's approach," Brad shared. "It was mature."
The 51-year-old actor explained that Ange could only just make the best of the situation.
"There was a strength in that. It was just another one of those things in life that makes you tighter and she was doing it for the kids, and she was doing it for her family so we could be together," he said.
With a defective BRCA1 gene, Angelina, 40, learnt that she had an 87 per cent chance of developing breast cancer. She also had a 50 per cent chance of developing ovarian cancer.
Angelina's mother Marcheline Bertrand passed away at the age of 56, after being diagnosed with cancer.
Ange revealed how her mother had a secret pact with her surgeon.
"We had some of the same nurses, some of the same doctors," the actress shared with The Today Show.
"So, the doctor that did my ovary surgery was my mother's doctor," Ange went on to say. "And apparently my mother had said to her, "promise me you will take Angie's ovaries out. So when we kind of got together, we both had a big cry, and she said, "I promised your mother, and I gotta do this.'"
Angelina's new film By The Sea, which also stars husband Brad, was inspired by the pain of losing her mother.
"We can't say what the whole film is about, but a lot of the film was when I went to visit my mum in the hospital, when she found out she had cancer the first time, she was gonna have her ovaries removed, (and) she was very upset, feeling like...they're taking out her parts that were female, and there was a woman down the hall who was wailing," Angelina revealed. "I later found out it was a young woman who had not had children yet, and that put everything into perspective."
"Every woman is different when they go through menopause, and...I didn't know emotionally how I would feel," Ange went on to say. "I knew the breast would be a bigger surgery and physically changing. The ovaries is more, your hormones changing and your emotions changing, but it's different. You feel different."
The whole ordeal brought the pair closer together. "She was doing it for the kids," Brad gushed about his wife. "And she was doing it for her family so we could be together."
"I knew through the surgeries that he was on my side and that this wasn't something where I was gonna feel less of a woman because my husband wasn't gonna let that happen," Ange added. "To face these issues together and speak about them and talk about what it is to be human, I think can be a beautiful thing."
By The Sea will be the first time the pair have reunited on screen, since Mr And Mrs Smith in 2005.
Brad and Angelina have six children, and married in 2014 after nine years together.