Two women from different areas venture out of their comfort zones and into a new part of the country to holidate in a city completely unlike where they currently live. Once they switch cities, each woman explores her new surroundings and embarks on a series of 3 dates hand-selected by the other lady. The women leave their old lives behind and look for Mr. Right in the sexiness of Santa Fe, the mystery of Miami, or the non-stop nightlife in New York. In the end, each girl invites one of her holidates to fly out and visit her in her hometown.